Increased Dickkopf-1 expression in breast cancer bone metastases

Zosteriform Skin Metastases from Breast Cancer

Metastatic skin cancer is a rare complication of internal malignancies.  Patients who develop cutaneous metastases rarely present with a zosteriform distribution.  Herein, we describe a 65-year-old woman with a prior history of breast cancer in whom zosteriform metastases developed along her left T8-9 abdominal dermatomes.

Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.

Hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. The transcription factor hypoxia-inducible factor-1 (HIF-1) is a major regulator of adaptation to hypoxia and is implicated in the malignant progression of cancers. Here, we studied whether hypoxia and HIF-1 expression contribute to the development of bone metastases using a well-characterized animal m...

Enhance Osteolytic Bone Metastases of Breast Cancer Hypoxia and Hypoxia-Inducible Factor-1 Expression

Hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. The transcription factor hypoxia-inducible factor-1 (HIF-1) is a major regulator of adaptation to hypoxia and is implicated in the malignant progression of cancers. Here, we studied whether hypoxia and HIF-1 expression contribute to the development of bone metastases using a well-characterized animal m...

Skin metastases in breast cancer: a review article

Mechanisms of bone metastases of breast cancer.

Cancer development is a multi-step process driven by genetic alterations that elicit the progressive transformation of normal human cells into highly malignant derivatives. The altered cell proliferation phenotype of cancer involves a poorly characterized sequence of molecular events, which often result in the development of distant metastasis. In the case of breast cancer, the skeleton is amon...